variations of glucose 6-phosphate dehydrogenase activity in various tissues induced by metabolic alkalosis, acidosis and diabetes

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چکیده

the effects of chronic metabolic acidosis, alkalosis and alloxan-induced ketoacidosis on g6pd activity of rat kidney, liver and erythrocytes were studied. metabolic acidosis significantly increased the activity of kidney enzyme (55%) but decreased the liver (43%) and erythrocyte (38%) enzyme activities. alkalosis did not make a significant change in the kidney or liver enzyme activity but slightly decreased that of the erythrocyte enzyme. in alloxan-induced diabetic rats, the rise in g6pd activity of kidney (69%) was associated with a decline in the enzyme activities of liver (50%) and erythrocytes (51%). it is suggested that in alloxan-induced diabetes, ketoacidosis is mainly responsible for the change in g6pd activity of various tissues and different organs do not respond similarly toward metabolic acidosis or alkalosis.

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VARIATIONS OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE ACTIVITY IN VARIOUS TISSUES INDUCED BY METABOLIC ALKALOSIS, ACIDOSIS AND DIABETES

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عنوان ژورنال:
journal of sciences islamic republic of iran

جلد ۵، شماره ۳، صفحات ۰-۰

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